I just finished my cockpit prototype based on Zyt 90-155 motors driven by 12v12 jrk. Everything works fine under jrk configuration utility (speed, pid, min, max...).
But when I launch X-Sim, I get that : "error opening USO comport..." for my 2 jrk (com4 and com6).

I am using usb cable from pololu. I have just ordered new one on amazon. Hope it will help !